www.lesswrong.com/posts/E9xfgJHvs6M55kABD/less-dead
1 correction found
current neuroscience says long-term memories are preserved
Current neuroscience does not say preserved ultrastructure definitively preserves long-term memories. The question is still unresolved and lacks professional consensus.
Full reasoning
This sentence overstates the state of the science.
The Brain Preservation Foundation — the organization that awarded the ASC prize cited elsewhere in the post — explicitly says that validation for human-use memory preservation has not yet occurred. Its position statement says that many neuroscientists think preserving the connectome alone may not be sufficient, that we still do not fully understand how many kinds of memory are stored, and that discussion and consensus about ASC's adequacy for preserving useful human memories has not happened. In its words: "Until a minority professional consensus emerges around this question, validation of preservation's value for human use has not occurred."
The BPF's accreditation page is similar: it says current consensus is that long-term information is primarily stored in synaptic patterns, but also notes that additional factors beyond traceability — such as receptor types, intrinsic neuronal plasticity, and molecular states — may also prove important for complete information retention.
Even Nectome's own linked writeup frames this as a hypothesis, not a settled result: its page is titled "The Long-Term Memory Preservation Hypothesis" and says glutaraldehyde fixation "may be able to preserve" memory and "may preserve memory."
So the evidence may support a plausible hypothesis, but it is not accurate to say that current neuroscience says long-term memories are preserved by this protocol.
3 sources
- The Brain Preservation Foundation
Many neuroscientists would agree that preserving the connectome alone may not be sufficient to preserve memory... We do not yet have a full understanding of how the many varieties of memory are stored... discussion and consensus with respect to ASC's potential adequacy ... has not happened... Until a minority professional consensus emerges around this question, validation of preservation's value for human use has not occurred.
- Standards/Accreditation - The Brain Preservation Foundation
Current neuroscientific consensus holds that information ... is primarily stored in the pattern of synaptic connections... While additional factors beyond traceability — such as specific receptor types, intrinsic neuronal plasticity, and molecular phosphorylation states — may also prove important for complete information retention...
- The Long-Term Memory Preservation Hypothesis
I present the long-term memory preservation hypothesis: the idea that glutaraldehyde fixation may be able to preserve... Which suggests the the conclusion: Glutaraldehyde may preserve memory.