en.wikipedia.org/wiki/List_of_human_cell_types
7 corrections found
bicarbonate and digestive enzyme secretion
Pancreatic acinar cells secrete digestive enzymes, while bicarbonate-rich fluid is secreted by pancreatic duct/ductal cells, not acinar cells.
Full reasoning
This function assignment conflates two different exocrine pancreatic cell types. A review in Gut states that acinar cells are responsible for the synthesis, storage, and excretion of pancreatic digestive enzymes, whereas duct cells are responsible for secreting a bicarbonate-rich isotonic solution that transports those enzymes and neutralizes gastric acid. The same review also notes that pancreatic fluid and HCO3− secretion are duct-cell functions, while digestive enzyme secretion is an acinar-cell function.
So the table entry is inaccurate as written: pancreatic acinar cells should not be described as performing “bicarbonate and digestive enzyme secretion.”
2 sources
- The acinar-ductal tango in the pathogenesis of acute pancreatitis - PMC
The acinar cell is responsible for the synthesis, storage and excretion of pancreatic digestive enzymes into the lumen, and the duct cells form the pancreatic ductal system responsible for secreting a bicarbonate-rich isotonic solution.
- The acinar-ductal tango in the pathogenesis of acute pancreatitis - PMC
It has been recently shown that pancreatic fluid and HCO3− secretion by the duct cells and digestive enzyme secretion by acinar cells are severely compromised in patients with autoimmune pancreatitis.
secreting estrogen
Theca interna cells primarily produce androgens; those androgens are converted into estrogens by granulosa cells.
Full reasoning
This entry assigns the wrong principal steroid product to theca interna cells. The NCBI MeSH entry for Theca Cells says that thecal interstitial/stromal cells are steroidogenic and produce primarily androgens, which then serve as precursors of estrogens in granulosa cells. In other words, estrogen production is primarily attributed to granulosa-cell aromatization of theca-derived androgens, not direct estrogen secretion by theca interna cells.
Because the article specifically labels the theca interna cell as “secreting estrogen,” it misstates the usual endocrine role of that cell type.
1 source
- Theca Cells - MeSH - NCBI
Thecal interstitial or stromal cells are steroidogenic, and produce primarily ANDROGENS which serve as precusors of ESTROGENS in the GRANULOSA CELLS.
Outer hair cells of vestibular system of ear
“Outer hair cells” are cochlear hearing cells. Vestibular hair cells are classified as type 1 and type 2, not inner and outer hair cells.
Full reasoning
This mislabels a vestibular cell type using cochlear terminology. The NCBI Bookshelf chapter on the vestibular system explains that the sensory epithelia of the vestibular apparatus contain hair cells that are divided into Type 1 and Type 2 hair cells. By contrast, Baylor Medicine’s description of the organ of Corti in the cochlea describes inner hair cells and outer hair cells as the hearing-cell types found in the cochlea.
So “outer hair cells of vestibular system of ear” is anatomically incorrect: outer hair cells are cochlear, not vestibular.
2 sources
- Physiology, Vestibular System - StatPearls - NCBI Bookshelf
Hair cells are divided into Type 1 hair cells and Type 2 hair cells.
- Organ of Corti | Baylor Medicine
A single flask shaped inner hair cell is shown on the left and three rows of cylindrically shaped outer hair cells are seen on the right.
Inner hair cells of vestibular system of ear
“Inner hair cells” are cochlear hearing cells. Vestibular hair cells are type 1 and type 2, not inner hair cells.
Full reasoning
This is the same terminology error in the next row. The vestibular apparatus contains Type 1 and Type 2 hair cells, as described in the NCBI Bookshelf vestibular-system chapter. Inner hair cells are instead a cochlear cell type in the organ of Corti, where Baylor Medicine describes one row of inner hair cells and three rows of outer hair cells.
So “inner hair cells of vestibular system of ear” is incorrect nomenclature for vestibular sensory cells.
2 sources
- Physiology, Vestibular System - StatPearls - NCBI Bookshelf
Hair cells are divided into Type 1 hair cells and Type 2 hair cells.
- Organ of Corti | Baylor Medicine
A single flask shaped inner hair cell is shown on the left and three rows of cylindrically shaped outer hair cells are seen on the right.
ABCC9, KCNJ8, RGS5
These are widely used pericyte/mural-cell markers, not standard endothelial-cell biomarkers.
Full reasoning
The biomarker list attached here to endothelial cells is inconsistent with vascular cell-marker literature. A 2024 Nature Medicine vascular-cell atlas states that capillary pericytes are characterized by expression of ABCC9, KCNJ8, and RGS5. Likewise, a 2024 Journal of Neuroscience paper on pericyte markers explains that Kcnj8 marks pericytes (with Cldn5 marking endothelial cells) and describes RGS5 as a broadly used pericyte marker; it also notes that Abcc9- and Kcnj8-based models show specificity to pericytes.
So listing ABCC9, KCNJ8, RGS5 as endothelial-cell biomarkers is misleading: these genes are primarily associated with pericytes / mural cells, not endothelial cells.
3 sources
- An organotypic atlas of human vascular cells | Nature Medicine
Within the pericyte compartment, general capillary pericytes (cap_pc) were shared among organs and were characterized by expression of known markers ABCC9, KCNJ8 and RGS5, and absence of pan-VSMC marker MYH11.
- Atp13a5 Marker Reveals Pericyte Specification in the Mouse Central Nervous System - PMC
These include, but are not limited to, Snap25 for neuron, Cldn10 for astrocyte, Mbp for oligodendrocyte, Cldn5 for EC, Kcnj8 for PC, Acta2 for VSMC, Ctss for microglial, and Col1a1 for fibroblast-like cell.
- RGS5 expression is a quantitative measure of pericyte coverage of blood vessels - PubMed
by analyzing the expression of the pericyte-specific gene, the regulator of G-protein signaling 5 (RGS5).
Columbia University Medical Center at Columbia University
The Human Cell Atlas is not a Columbia University Medical Center project; it is an international consortium.
Full reasoning
The table’s Provider entry for the Human Cell Atlas is incorrect. The official HCA Data Portal describes the Human Cell Atlas as “a collaborative community of international scientists” and says its registry includes more than one thousand member scientists from hundreds of institutions around the world. That directly conflicts with listing Columbia University Medical Center at Columbia University as the provider of the Human Cell Atlas.
Columbia researchers may participate in HCA-related work, but the Human Cell Atlas itself is a global consortium rather than a Columbia-run database.
2 sources
- About the Human Cell Atlas - HCA Data Portal
The Human Cell Atlas (HCA) is a collaborative community of international scientists. The HCA registry has more than one thousand member scientists from hundreds of institutions around the world.
- Human Cell Atlas
The Human Cell Atlas is a global consortium that is mapping every cell type in the human body.
37 trillion cells
The Human Cell Atlas does not currently contain 37 trillion profiled cells; its official data portal reports tens of millions of cells, not trillions.
Full reasoning
This value appears to confuse the estimated number of cells in a human body with the number of cells actually represented in the Human Cell Atlas database. The official HCA Data Portal says the HCA community is profiling millions of human cells, and the current portal overview reports 70.8 million cells. That is many orders of magnitude smaller than 37 trillion.
So the table entry is factually incorrect as a measure of how many cells the Human Cell Atlas has identified or contains so far.
2 sources
- About the HCA Data Portal - HCA Data Portal
The HCA community is profiling millions of human cells, a process that generates enormous amounts of data that scientists need to store, standardize and interpret.
- HCA Data Portal
Explore the datasets of the Human Cell Atlas ... 70.8M Cells