en.wikipedia.org/wiki/Siege_of_Acre_(1291)

The wording says Acre's Latin Christian population was killed or enslaved, which implies there were no substantial survivors. But contemporary and modern sources both state that large numbers escaped.

A translated medieval source collected by Fordham's Internet History Sourcebooks says that when Acre fell, "more than one hundred thousand men escaped to Cyprus". Even allowing for medieval chroniclers' exaggeration in raw numbers, that source plainly contradicts the claim that the population was simply killed or enslaved.

Modern secondary history also says many refugees got out. World History Encyclopedia notes that many civilians had already fled the city, and that the Hospitallers helped many refugees escape to the safety of Cyprus after the fall.

So a more accurate formulation would be that many inhabitants were killed or enslaved, while many others escaped by sea, especially to Cyprus.

This claim is too categorical. Acre's fall was the end of permanent Crusader control on the mainland, but authoritative histories do not treat it as the end of all later crusading efforts directed back toward the eastern Mediterranean.

Britannica states that after 1291 various crusade projects were still being proposed, and, crucially, that there were later "attempts to regain a foothold on the mainland". That directly contradicts the idea that Acre's capture ended any further crusading aimed at the Levant.

Britannica's general overview of the Crusades likewise says that the crusading movement continued for several centuries after 1291. So while Acre marked a decisive break and the loss of the last major mainland stronghold, it did not literally end further crusading efforts toward the region.