unorthodoxy.substack.com/p/how-pharma-turns-clinical-trials?just_subscribed=true
6 corrections found
病毒并不存在
This is false. Viruses are directly observed, isolated, sequenced, and experimentally characterized biological entities.
Full reasoning
The existence of viruses is not speculative.
- The National Library of Medicine's NCBI Bookshelf defines viruses as microscopic entities with DNA or RNA, and notes that virus particles (virions) can be quantified visually by electron and epifluorescence microscopy.
- CDC researchers reported isolating SARS-CoV-2 from a U.S. patient and characterizing its viral sequence, replication properties, and cell-culture behavior.
Those are direct lines of evidence—microscopy, isolation, genome sequencing, and laboratory culture—that contradict the claim that viruses do not exist.
2 sources
- WHAT IS A VIRUS? - NCBI Bookshelf
Viruses are microscopic entities... Virus particles or virions are comprised of genetic material... Virions can be quantified visually by electron and epifluorescence microscopy.
- Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States - CDC
We isolated virus from nasopharyngeal and oropharyngeal specimens from this patient and characterized the viral sequence, replication properties, and cell culture tropism.
没有人死于新冠
This is false. COVID-19 has caused millions of confirmed deaths worldwide, and U.S. death certificates record large numbers of deaths involving COVID-19.
Full reasoning
Authoritative public-health sources directly contradict the statement that "no one died of COVID-19."
- The World Health Organization states that as of June 28, 2026, more than seven million confirmed deaths from COVID-19 had been reported worldwide.
- The U.S. CDC's National Center for Health Statistics maintains a mortality surveillance page based on death certificates and explains that COVID-19 deaths are coded when COVID-19 is reported as a cause contributing to death. The page documents ongoing U.S. counts of deaths involving COVID-19.
Because these are official mortality records and global surveillance totals, the claim that nobody died from COVID-19 is factually incorrect.
2 sources
- WHO COVID-19 Global Risk Assessment- Version 10
As of 28 June 2026, over 779 million confirmed cases and over seven million confirmed deaths have been reported globally to WHO since the event was confirmed to WHO in 2020.
- Provisional COVID-19 Mortality Surveillance
The provisional counts for COVID-19 deaths are based on a current flow of mortality data in the National Vital Statistics System... COVID-19 deaths are identified using the ICD-10 code U07.1.
新冠疫情不过是流感
This is incorrect. COVID-19 and influenza are different diseases caused by different viruses, and health authorities explicitly distinguish them.
Full reasoning
WHO and CDC both state that COVID-19 and influenza are not the same disease.
- WHO says COVID-19 and seasonal influenza are respiratory infections caused by two different viruses: SARS-CoV-2 causes COVID-19, while influenza viruses cause flu.
- CDC likewise says COVID-19 is caused by infection with SARS-CoV-2, whereas flu is caused by influenza viruses.
The two illnesses can share some symptoms, but calling COVID-19 "just flu" is factually wrong because it misidentifies the disease itself.
2 sources
- Coronavirus disease (COVID-19): Similarities and differences between COVID-19 and Influenza
COVID-19 and seasonal influenza (flu) are respiratory infections caused by two different viruses... SARS-CoV-2 causes COVID-19 and influenza viruses cause influenza.
- Similarities and Differences between Flu and COVID-19 | CDC
Influenza (flu) and COVID-19 are both contagious respiratory illnesses, but they are caused by different viruses. COVID-19 is caused by infection with a coronavirus (SARS-CoV-2)... Flu is caused by infection with an influenza virus.
恐龙曾经存在过,或者地球在自转
Both parts of this claim are false. Dinosaur fossils are extensively documented, and Earth’s rotation is directly measured and described by NASA.
Full reasoning
This sentence denies two well-established facts.
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Dinosaurs existed. The U.S. National Park Service states that dinosaurs are documented in the fossil record, including body fossils and trace fossils, and explains that our direct evidence comes from Triassic, Jurassic, and Cretaceous rock formations. NPS also notes that body and trace fossils of non-avian dinosaurs have been documented from at least 21 National Park Service areas.
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Earth rotates. NASA states that as Earth orbits the Sun, it completes one rotation every 23.9 hours. NASA also describes Earth's axis of rotation and related rotational motion in its Earth science materials.
These are basic conclusions supported by physical evidence—fossils in the geologic record and astronomical/geophysical measurements of Earth's motion.
3 sources
- Dinosaurs in the Fossil Record - U.S. National Park Service
Yet, we know they were real... All of our direct evidence of dinosaurs comes from the geologic record... Dinosaur fossils come in two forms: body fossils and trace fossils.
- Dinosaurs - Fossils and Paleontology - U.S. National Park Service
Body and trace fossils of non-avian dinosaurs have been documented from at least 21 NPS areas.
- Facts About Earth - NASA
As Earth orbits the Sun, it completes one rotation every 23.9 hours.
癌症不是遗传性疾病。癌症纯粹是代谢性疾病
This is false. The National Cancer Institute states that cancer is a genetic disease caused by changes in genes, not a purely metabolic disease.
Full reasoning
The National Cancer Institute directly contradicts this claim.
- NCI states plainly: "Yes, cancer is a genetic disease. It is caused by changes in genes that control the way cells grow and multiply."
- NCI also explains that cancer is caused by DNA changes in genes and that these changes can activate oncogenes or disable tumor suppressor genes.
Cancer biology does involve metabolism, but the categorical statement that cancer is not a genetic disease and is purely metabolic is inconsistent with the mainstream evidence base summarized by NCI.
2 sources
- The Genetics of Cancer - National Cancer Institute
Yes, cancer is a genetic disease. It is caused by changes in genes that control the way cells grow and multiply.
- What Is Cancer? - National Cancer Institute
Cancer is a disease caused when cells divide uncontrollably... A DNA change can cause genes involved in normal cell growth to become oncogenes... DNA changes that inactivate tumor suppressor genes can lead to uncontrolled cell growth and cancer.
即我们自身的mRNA
This misdescribes the drug. Intismeran autogene is not a patient’s naturally occurring mRNA; Merck describes it as a synthetic mRNA therapy designed from the tumor’s mutational signature.
Full reasoning
Company and NCI materials describe intismeran autogene/V940 as synthetic mRNA, not as a patient's own preexisting mRNA.
- Merck says intismeran autogene is an investigational mRNA-based individualized neoantigen therapy consisting of "a synthetic mRNA coding for up to 34 neoantigens" designed from the DNA sequence of the patient's tumor.
- Merck has also described mRNA-4157/V940 as a personalized mRNA cancer vaccine built to stimulate T-cell responses based on the tumor's mutation signature.
So calling it "our own mRNA" is inaccurate. It is a custom-designed synthetic product derived from analysis of the patient's tumor, not the person's naturally occurring endogenous mRNA.
2 sources
- Merck Highlights New Long-Term Data and Advancements Across Broad Oncology Portfolio and Pipeline Research at ASCO 2026
Intismeran autogene is a novel investigational messenger RNA (mRNA)-based individualized neoantigen therapy (INT) consisting of a synthetic mRNA coding for up to 34 neoantigens that is designed and produced based on the unique mutational signature of the DNA sequence of the patient’s tumor.
- Moderna and Merck Announce mRNA-4157/V940... Met Primary Efficacy Endpoint in Phase 2b KEYNOTE-942 Trial
mRNA-4157/V940 is a novel investigational messenger ribonucleic acid (mRNA)-based personalized cancer vaccine consisting of a single synthetic mRNA coding for up to 34 neoantigens...